In Client successes

Publication Success!

Findings published in Frontiers in Immunology earlier this year show that hepcidin is a potent marker of septic shock and other acute inflammation-associated pathologies!

Marcela Hortova-Kohoutkova and colleagues aimed to understand whether the dynamics of iron regulation could be used as a biomarker for inflammatory disease severity. In their cohort, comprising patients with #septicshock and #covid19, they saw that elevated hepcidin levels reflect overall immune-cell activation driven by intrinsic stimuli, while ferritin levels were boosted by pathogen-induced inflammation.

Hortová-Kohoutková et al. ultimately propose that the hepcidin-to-ferritin ratio could identify those at risk of mortality in septic shock. These findings have amazing clinical potential and we are really excited to see how they translate going forward!

Check out the full, open-access article here: https://lnkd.in/e8XYBsg9

Congratulations to the whole team involved in this work – Insight Editing London’s Daniel Ackerman enjoyed working with you all on this paper!

In Client successes

Publication success!

Hot off the press: a new review article has been published in Trends in Paristology on helminth infections in cattle.

Here, Johannes Charlier, Diana Williams, Nadine Ravinet and Edwin Claerebout discuss how by combining refined diagnostic thresholds with farm-specific information on grazing systems and animal history, farmers can tailor helminth treatments to ultimately limit anthelmintic resistance and boost agricultural efficiency and food security.

You can access the paper here if you would like to find out more: https://lnkd.in/dqaNHgMk

Congratulations to all those involved in this interesting article – it was a pleasure working with you!

In Client successes

Publication success!

We’re really excited to see the latest paper from Jerome Tamburini and colleagues published just last month in Leukemia journal.

In this study, Tamburini et al. investigated how mitochondrial metabolism is linked to acute myeloid leukemia (AML). Using patient-derived xenograft models, they found that blocking mitochondrial fusion resulted in anti-leukemic cellular activity, with minimal impact on normal hematopoietic cells.

You can find out more about the underlying mechanisms of this intriguing process, here: https://lnkd.in/eWvwR65h

IEL offers congratulations to all those involved in this impactful study. It’s exciting to see that inhibiting mitochondrial fusion might one day constitute a potential therapeutic approach for those with AML.

In Client successes

Many congratulations to Annalisa Terranegra and colleagues at Sidra Medicine on their latest publication in the journal Biomedicine and Pharmacotherapy!

In their paper, the authors demonstrated a reduction of the genus Bifidobacterium in the gut microbiome of pediatric type 1 diabetes patients with elevated blood pressure, finding a link with elevated lipopolysaccharide synthesis and glutathione metabolism.

Learn more by checking out the full article:

https://lnkd.in/dsAxDY6

Congrats again to the Terranegra team and their collaborators!