In Blog

Perfecting your presentation

So far, we have thought about how to select a review topic and reach out to a target journal. Now that you have your structure, bibliography, and potential target journal in place – you are finally ready to write your review! In this final blog post, I will share with you a few tips and tricks to write a clear, concise and effective review article.

All the principles of good science writing apply, but ensuring clarity and concision are at the top of my list. It is tempting to write a thesis on your favourite subject, but consider your audience, their attention span and their time available to read your review. An effective review is often around 3,000-5,000 words (although some journals accept longer). If you think you will greatly exceed this word count, then perhaps your topic is too broad or you have started to diverge away from your original topic. The good news is that this might mean you have enough material to write another review later down the track!

Primary research articles are exciting and interesting because they are full of new data with supporting figures and tables. Make sure you bring the same level of interest to your review article. Blocks of unbroken text are daunting and off-putting to read. Aim for at least one display item to accompany each main section of your review: perhaps a cartoon, schematic, table, graph, or information box. Whatever you create, make it novel, informative and interesting. Remember – display items from reviews are often heavily recycled in conference talks and posters, and so serve as great advertising for your article and your research team!

Research articles condense the excitement of unraveling new data: how can you bring that level of intrigue to a review article? While a review article doesn’t necessarily include new data, you can still offer your unique opinion. Much of your audience will have chosen to read your review because of your authoritative position in the field, and others might be looking for inspiration. So, create a buzz by offering some speculation and suggesting new avenues for research and development in the field. Just make sure you explain that this is just your opinion (of many alternatives) and not necessarily consensus!

Finally, you should consider who is going to co-author your review if you choose not to fly solo. Review articles tend to include just a handful of authors who are ideally from different labs, representing different opinions and expertise. Including your entire research group is discouraged — rather, your audience will want to see that your review has been crafted by a select group of experts. To avoid arguments, think about this sooner rather than later!

We hope you found this series of blog posts on writing un-commissioned reviews helpful. The IEL team look forward to seeing what you produce over the coming year.

In Client successes

Publication of a new method!

We are delighted to share that yet another paper from Lukas Flatz and colleagues is now available online at Science Immunology!

Here, Flatz et al. present their method “DITAS”, which they show can help discover tumor-associated self-antigens. They developed DITAS in the context of non-small cell lung cancer (NSCLC), analyzing the shared antigens between NSCLC and normal lung tissue. After detecting lung tissue–specific genes highly expressed in lung tumors and validating candidate antigens, they identified napsin A that could induce NSCLC and lung reactive CD8+ T cell responses.

These exciting data might hold the key to improving immune checkpoint blockade, which despite its efficacy, in many patients has to be ceased due to the onset of immune-related adverse events.

Find out more about DITAS and the potential role of napsin A, here: https://lnkd.in/dK4vniZa

Congratulations to all those involved in this exciting study! Insight Editing London‘s Lucy Robinson really enjoyed working on this paper with you.

In Client successes

New review article!

Would you like to learn more about how spatially resolved transcriptomics (SRT) can be applied to your field of interest? If so, you might like to check out this recent review published in Blood Science: https://lnkd.in/diGqQZsy

In this article, Honglin Duan, Tao Cheng and Hui Cheng based at the Institute of Hematology and Blood Diseases Hospital (Tianjin, China) update us on the new technologies permitting high-resolution, high-throughput and multiplex SRT. Their review highlights that the possibilities to unravel the molecular architecture of tissues are endless thanks to these great technological advances.

Thank you to the researchers for giving us a sneak peek at this work before submission – we really enjoyed working with you!

In Client successes

Publication success!

We have another paper from our colleague Joe YEONG 杨宝诚 and his collaborators in Singapore to highlight! Joe Yeong et al. have published data from another intriguing case study showing that residual SARS-CoV-2 antigen and RNA can persist in various tissues of long-COVID-19 patients, even beyond a year since SARS-CoV-2 infection.

While these data have been generated from only two cases, other reports are emerging elsewhere of SARS-CoV-2 reservoirs in gastrointestinal and non-gastrointestinal tissues. It therefore seems possible that such viral persistence is underlying long Covid-19 symptoms in affected patients.

Take a read for yourself – the data are fascinating!
https://lnkd.in/d9AjgeEY

Nice work Joe YEONG 杨宝诚 et al. – it’s always a pleasure to work with you!

In Client successes

Publication success!

Despite life for many returning to something a little more “normal” since the Covid-19 pandemic took hold in 2019, the number of cancer patients with covid comorbidity continues to rise. Management strategies for these affected patients are urgently needed.

Now, Maichan LauJoe YEONG 杨宝诚 and colleagues at the Institute of Molecular and Cell BiologyDuke-NUS Medical SchoolSingapore General HospitalCancer Science Institute of Singapore and the National Cancer Centre Singapore, have reported their initial findings on how SARS-CoV-2 infection might impact on cancer patients and their treatment.

Leveraging a spatial whole-transcriptomics analysis approach, the researchers found that SARS-CoV-2 infection might induce a persistent, immunological memory that could offer tissue-level protection against reinfection and perhaps even modulate the tumour microenvironment to favour immune checkpoint blockade responses!

Find out more in their paper published earlier this year in Frontiers in Immunology:
https://lnkd.in/dKvw3HV5

Congratulations to this great team based in Singapore for this highly relevant and impactful work!

In Client successes

New publication!

Delia Grace and colleagues have proposed a new framework to optimise the potential of working equids (e.g. horses, donkeys, mules and hinnies) to small farms in low- and middle-income countries.

Their framework – published in PLOS ONE in September – derives from the results of an extensive literature review and survey of working equids welfare experts. In their paper, you can learn more about the varied roles of working equids and the ongoing barriers to optimizing their contributions to sustainable development goals. Check out the full text here: https://lnkd.in/dJbsKnp8

Well done to all those who contributed to this important work, and thank you for involving Insight Editing London editor Daniel Ackerman during your manuscript preparation!