In Client successes

New review article!

Did you know that chronic stress is a risk factor for developing psychiatric conditions?

If this is news to you, then you might like to check out this review article published in Neurology – Neuroimmunology & Neuroinflammation earlier this year: https://lnkd.in/dAuWvwQa

Here, Eva Schramm and Ari Waisman will guide you through the axis linking chronic stress with immune system activation. They neatly explain how chronic stress can activate and then alter the phenotype and function of microglia in defined brain regions. By the end, you should see how, given their strategic location within the central nervous system, microglia are important mediators of psychopathologies.

Congratulations to Eva and Ari for compiling this intriguing review – we were delighted to take a sneak peek before submission!

In Blog

In my previous post, I outlined how to identify a novel review topic. Now you have your great idea for a review article ready, you might think that this is the time to start writing. While this strategy can pay off for some, it is a risky and often time-consuming approach. The fact is that some journals do not accept unsolicited reviews, while others do but with varying frequency. This doesn’t mean that you can’t write a review if you haven’t been asked to do so; but, reaching out to the journal at an early stage can save you time if the journal is not interested, already has plans to cover your topic, or might like to modify your ideas to suit their needs.

Before we talk about how to approach the journal, let’s think about why reaching out during the planning stage of the review is a good idea. Most reviews in top journals are commissioned by journal editors because review articles typically bring in the bulk of a journal’s annual citations. If a journal misreads their audience (or their competitors) and chooses the “wrong topic” to review, they can potentially reduce their next year’s impact factor. So, journal editors take great care when thinking about the next review they publish. This means that your pre-submission enquiry needs to be sensitive to these issues: you need to explain the novelty of your review, how it will align with the journal’s scope and readership’s interests, and why having a review written by you is going to attract citations for their journal.

Next, we need to think about where to reach out to. Statistically, it is unlikely that the first journal you pitch your idea to is going to be the one that wants to roll with it. So it’s a good idea to start by generating a list of potential target journals and to work through it by sending out pre-submission enquiries. To produce this all important list, you could establish where most of the cited primary research papers you identified in your literature search have been published: do any of these journals publish reviews and consider unsolicited requests? If so, then note them down and take a look at their website for other useful information and to make sure that your proposed piece fits well with their published scope. You might also look at journals where you have successfully published your research in recent years and so have an “exsiting relationship”, as they will already know the quality of your work and writing. The good news is that, unlike the submission of the article itself, there is nothing to stop you sending enquiries to several different journals at once, so set aside an afternoon and get emailing!

When you contact your target journals, what do you need to tell them? The basics of a pre-submission enquiry should ideally include the following:

  • Your proposed title and author list
  • An outline of your expertise to write an authoritative review
  • Your top 10-15 selected references from the bibliography
  • A draft of your figures and tables
  • An outline of the key points – perhaps your section headings and figure titles

Also in the covering letter you should state clearly why you think that their journal is a great match for the work, for example how it will appeal to different sectors of their readership, and how you anticipate it will generate interest and/or new research ideas across the field. If it is an opinionated review, are you suporting a new or controversial viewpoint that will get people talking? Is your review particularly timely, coming off the back of a new and exciting discovery, or quesitoning an established dogma? These are all things that will help attract readers, and so will help generate editorial interest in your proposal.

By approaching several journals at this stage, before you’ve written the full text, you avoid both the risk of investing a lot of time in a draft that a journal might then request major changes to, and the stress of having a finalised document and struggling to find someone to publish it. Moreover, most journal editors will appreciate the opportunity to collaborate with you on your review article so that the content is likely to attract as many of their readers as possible. It’s a win win!

In Client successes

We are pleased to highlight the latest study by Dr. Joe Yeong PohSheng and colleagues in Singapore published in GUT (BMJ) this month. The researchers report that Covid-19 survivors have viral antigen/RNA detectable in their GI tract and liver up to 6 months after recovery.

The implications of this finding are huge when considering disease management and public health policy in the context of Covid-19 transmission via the faecal-oral route and aerosol-generating procedures. Future work to validate these early findings are certainly warranted!

To learn more, check out the full paper here: Residual SARS-CoV-2 viral antigens detected in GI and hepatic tissues from five recovered patients with COVID-19 | Gut (bmj.com)

Many congratulations from the Insight Editing London team!

In Client successes

Many congratulations to Ammira Al-Shabeeb Akil and her colleagues at Sidra Medicine on the publication of their latest review article in the Journal of Translational Medicine (BMC)!

In their review, Akil et al. provide their expert perspective on how we might improve type 1 diabetes diagnostics and treatments as we enter the new era of personalised medicine.

The life-long consequences of type 1 diabetes are profound. Worryingly, the incidence of this disease is increasing, particularly in children. Improving our understanding and concentrating our research efforts on the risk factors, aetiology and pathology of this disease is, as the researchers explain, essential.

If you would like to learn about the latest discoveries in stem cell-based and  gene therapy-based treatments for type 1 diabetes, and the research questions that remain to be answered, download the full length, open access review article here:

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-02778-6

Congratulations again to the entire team who compiled this extensive review: we are sure that this article will be met with great interest by the clinical and research community!

In Client successes

BloodGen3Module: blood transcriptional module repertoire analysis and visualization using R

Damien Chaussabel and colleagues at Sidra Medicine, Qatar have released a third iteration of a fixed, reusable blood transcriptional module repertoire. “BloodGen3” comprises >380 functionally annotated modules that together serve as a huge resource to help analyse and interpret changes in blood transcript abundance observed across various physiological states.

Find out more by reading their latest publication in Bioinformatics (Oxford Academic):  https://doi.org/10.1093/bioinformatics/btab121

Congratulations to Darawan Rinchai, Jessica Roelands, Mohammed Toufiq, Wouter Hendrickx, Matthew C Altman, Davide Bedognetti and Damien Chaussabel!

In Client successes

Aspergillus fumigatus tryptophan metabolic route differently affects host immunity

Teresa Zelante and colleagues have published their latest findings on how fungal tryptophan metabolic pathways cooperate with the host xenobiotic response to shape host-microbe interactions in local tissue environments.

Their paper, published earlier this year in Cell Reports (Cell Press), is now available open access. Follow the link to learn more about how they collected these exciting data and what they mean in terms of the effects of Aspergillus fumigatus on host immunity.

Many congratulations to all the researchers involved!

Aspergillus fumigatus tryptophan metabolic route differently affects host immunity: Cell Reports