Highlighted Paper

We are pleased to highlight the latest study by Dr. Joe Yeong PohSheng and colleagues in Singapore published in GUT (BMJ) this month. The researchers report that Covid-19 survivors have viral antigen/RNA detectable in their GI tract and liver up to 6 months after recovery.

The implications of this finding are huge when considering disease management and public health policy in the context of Covid-19 transmission via the faecal-oral route and aerosol-generating procedures. Future work to validate these early findings are certainly warranted!

To learn more, check out the full paper here: Residual SARS-CoV-2 viral antigens detected in GI and hepatic tissues from five recovered patients with COVID-19 | Gut (bmj.com)

Many congratulations from the Insight Editing London team!

Many congratulations to Annalisa Terranegra and colleagues at Sidra Medicine on their latest publication in the journal Biomedicine and Pharmacotherapy!

In their paper, the authors demonstrated a reduction of the genus Bifidobacterium in the gut microbiome of pediatric type 1 diabetes patients with elevated blood pressure, finding a link with elevated lipopolysaccharide synthesis and glutathione metabolism.

Learn more by checking out the full article:

https://lnkd.in/dsAxDY6

Congrats again to the Terranegra team and their collaborators!

Many congratulations to Ammira Al-Shabeeb Akil and her colleagues at Sidra Medicine on the publication of their latest review article in the Journal of Translational Medicine (BMC)!

In their review, Akil et al. provide their expert perspective on how we might improve type 1 diabetes diagnostics and treatments as we enter the new era of personalised medicine.

The life-long consequences of type 1 diabetes are profound. Worryingly, the incidence of this disease is increasing, particularly in children. Improving our understanding and concentrating our research efforts on the risk factors, aetiology and pathology of this disease is, as the researchers explain, essential.

If you would like to learn about the latest discoveries in stem cell-based and  gene therapy-based treatments for type 1 diabetes, and the research questions that remain to be answered, download the full length, open access review article here:

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-02778-6

Congratulations again to the entire team who compiled this extensive review: we are sure that this article will be met with great interest by the clinical and research community!

BloodGen3Module: blood transcriptional module repertoire analysis and visualization using R

Damien Chaussabel and colleagues at Sidra Medicine, Qatar have released a third iteration of a fixed, reusable blood transcriptional module repertoire. “BloodGen3” comprises >380 functionally annotated modules that together serve as a huge resource to help analyse and interpret changes in blood transcript abundance observed across various physiological states.

Find out more by reading their latest publication in Bioinformatics (Oxford Academic):  https://doi.org/10.1093/bioinformatics/btab121

Congratulations to Darawan Rinchai, Jessica Roelands, Mohammed Toufiq, Wouter Hendrickx, Matthew C Altman, Davide Bedognetti and Damien Chaussabel!

Aspergillus fumigatus tryptophan metabolic route differently affects host immunity

Teresa Zelante and colleagues have published their latest findings on how fungal tryptophan metabolic pathways cooperate with the host xenobiotic response to shape host-microbe interactions in local tissue environments.

Their paper, published earlier this year in Cell Reports (Cell Press), is now available open access. Follow the link to learn more about how they collected these exciting data and what they mean in terms of the effects of Aspergillus fumigatus on host immunity.

Many congratulations to all the researchers involved!

Aspergillus fumigatus tryptophan metabolic route differently affects host immunity: Cell Reports

Reading between the (Genetic) Lines: How Epigenetics is Unlocking Novel Therapies for Type 1 Diabetes

Congratulations to Ammira-Sarah Akil and colleagues at Sidra Medicine on the publication of their latest review in Cells (MDPI)! In their article, Akil et al. outline the key epigenetic modifications associated with type 1 diabetes pathogenesis. They then speculate on how we might harness such epigenetic mechanisms to develop novel therapeutics.

To learn more about this fascinating topic, this review is available open access via the following link: https://www.mdpi.com/2073-4409/9/11/2403/htm