Mesenchymal stromal cells secrete immunosuppressive factors that could have great therapeutic potential. For this reason, they are being tested as a supportive treatment for graft versus host disease (GvHD). But how do these cells respond during fungal infection – a major cause of mortality in patients with GvHD? The latest paper from the Jan Fric lab at St. Anne’s University Hospital Brno, has some answers!
In their study – “NFAT signalling in human mesenchymal stromal cells affects extracellular matrix remodelling and anti-fungal immune responses” – Tidu et al. show that mesenchymal stromal cells engage the NFAT pathway in response to fungal infection, thus impacting extracellular matrix composition and immune cell functions.
To find out more, download the full text article from iScience today: https://doi.org/10.1016/j.isci.2021.102683.
Many congratulations to all the researchers involved in this interesting story!