In Client successes

New Review on the Multifaceted Roles of CD47! 🎉

Looking for some summer reading? Then I suggest the latest review on CD47, a receptor that is gaining increasing recognition for its versatile functions beyond its well-known role in preventing macrophage-mediated phagocytosis: https://www.nature.com/articles/s41418-024-01347-w

Published this July in Cell Death & Differentiation, this review delves deep into the emerging noncanonical roles of CD47, revealing its critical involvement in regulating processes such as proliferation, migration, apoptosis, differentiation, stress responses, and metabolism.

Key highlights from the review include:

  • An in-depth exploration of the cell-intrinsic signalling pathways regulated by CD47 across diverse cell types and environments.
  • Detailed discussion on pivotal pathways like PI3K/AKT, MAPK/ERK, and nitric oxide signalling, along with those involved in glucose, lipid, and mitochondrial metabolism.
  • Insights into how CD47’s interactions are often cell- and context-specific, adding layers of regulatory complexity.
  • The importance of these pathways in maintaining tissue homeostasis and the implications for understanding CD47’s role in various cancers.

Understanding these pathways not only broadens our knowledge of cellular processes but also paves the way for the development of innovative CD47-targeted therapies, especially given its dysregulation in numerous cancers.

Well done to the authors – @Ruhi Polara, @Raja Ganesan, @Stuart M. Pitson and @Nirmal Robinson – on their success! This review is sure to be an invaluable resource for researchers and clinicians alike.

#CD47 #CellBiology #CellSignaling #Review #InsightEditingLondon