In Client successes

A new study by Dandan Pi and colleagues at Chongqing Medical University unveils the role of dysregulated RAS in pediatric sepsis

In July this year, Dandan Pi and colleagues published their study on the role of the renin-angiotensin system (RAS) in pediatric sepsis in the leading journal Shock.

Pediatric sepsis is a life-threatening condition where the body’s response to infection leads to widespread inflammation and organ dysfunction. The RAS, a critical hormone system regulating blood pressure and fluid balance, is often disrupted during sepsis, worsening its severity by contributing to vascular instability, impaired immune response, and reduced organ perfusion. This study provides new insights into how RAS dysfunction influences the progression of sepsis in children, with potential implications for developing targeted treatment strategies.

Key findings include:

  1. Increased Renin Levels: Serum renin concentrations were significantly higher in sepsis patients compared to healthy controls.
  2. Decreased Angiotensin (1-7) Levels: Patients with sepsis exhibited lower levels of angiotensin (1-7), suggesting its potential as a biomarker for sepsis severity.
  3. Predictive Value: The combination of serum renin, angiotensin (1-7), and procalcitonin resulted in a diagnostic model with an AUROC of 0.87, indicating strong predictive accuracy for patient outcomes.

This research highlights the potential of circulating renin and angiotensin (1-7) as valuable biomarkers for pediatric sepsis, paving the way for improved diagnostic and therapeutic approaches to manage this critical condition in vulnerable young patients.

Join us in congratulating the authors on this groundbreaking work that enhances our understanding of pediatric sepsis! 🙌

For the full study, check it out here: Shock (lww.com)