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Did you know that the kinase MST1 is involved in endothelial dysfunction and atherosclerosis following disturbed blood flow in arterial regions?

Ai Ding and colleagues at Tianjin Medical University delved into this role of MST1 in their latest study published in Circulation Research (American Heart Association).

They showed that preserving MST1 kinase activity has an athero-protective effect that is achieved, in part, via MST1-mediated connexin Cx43 phosphorylation in endothelial cells.

The researchers speculate that as MST1 phosphorylation is restrained in response to the stress induced by disturbed blood flow, therapeutics designed around this new axis might prevent atherosclerotic plaques!

Find out more for yourself, here:

Well done to all those who contributed to this research – Insight Editing London’s Ilya Demchenko really enjoyed working on this paper with you!