Mechanisms of chemo-resistance in T-cell acute lymphoblastic leukemia

Publication success!

We are delighted to see that the latest study on the mechanisms of chemo-resistance in T-cell Acute Lymphoblastic #Leukemia (T-ALL) by Jingliao Zhang and colleagues is now published in the prestigious journal, Blood!

T-ALL is an aggressive cancer not least because of the propagation of resistant cancer clones that drive disease recurrence. Jingliao Zhang et al. (Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College) wanted to dissect the nature of these clones to work out how their presences might contribute to resistance to #chemotherapy .

Combining single cell RNA sequencing with T-cell receptor sequencing of paired diagnosis-relapse T-ALL samples, the researchers identified two leukemic evolutionary patterns: “clonal shift” and “clonal drift”. They additionally saw high expression of the RNA-binding protein MSI2 in the clones persisting at the point of disease relapse. Digging deeper, the researchers conducted functional studies showing that MSI2 contributed to T-ALL proliferation and promoted #chemoresistance through the posttranscriptional regulation of the #oncogene, MYC.

These findings have important implications, as they identify MSI2 as an informative biomarker and novel therapeutic target in T-ALL.

Congratulations to all those involved in this intricate study! For those of you who would like to learn more, the paper can be found online here: https://lnkd.in/dcRJVgr9

New insights into physiological and pathological brain wiring

We’re excited to share news of the publication of a fantastic article by an IEL client last month, edited by IEL’s Ilya Demchenko.

Published in PNAS as an open access article, Sinclair-Wilson and colleagues describe their ground-breaking work on the plasticity of brain circuits in neonates, which is important for the correction of embryonic thalamocortical axon mis-targeting. Using a genetic mouse model, the researchers identified a serotonin-dependent window in the immediate post-natal period in which pre-natal axon miswiring can be corrected and appropriate definition of cortical areas rescued: this period was disrupted by pre-term birth and dysregulation of serotonin levels. This work may have profound implications for our understanding of human neurodevelopmental disorders that occur in extremely pre-term infants.

You can find out everything you need to know by downloading the full text here: Plasticity of thalamocortical axons is regulated by serotonin levels modulated by preterm birth | PNAS

Well done to everyone involved in this groundbreaking study – it was a pleasure working with you and we look forward to learning how this work progresses in the future!

Publication success!

New findings on how pulmonary metastases form in gastric cancer (GC) have been published in the Journal of Cellular Biochemistry!

Ming Wang and colleagues at Henan University, investigated how extracellular vesicles known as exosomes might help GC cells metastasize to the lungs, using mouse forestomach carcinoma cells as their model system. They found a novel mechanism by which GC-derived exosomes mediate PD-L1 expression in lung macrophages (which helps cancer cells evade immune detection), which in turn facilitates lung pre-metastatic niche formation. Wang et al. hypothesize that these findings might one day translate into a future potential therapeutic target for GC with pulmonary metastases.

Find out more, here: https://onlinelibrary.wiley.com/doi/10.1002/jcb.30390

Well done to the authors involved in this insightful study – it was a pleasure to work with you and learn more about this exciting research!

 

Publication Success!

Earlier this month, Springer Nature Technology and Publishing Solutions published the Handbook of Cancer and Immunology, and it is a “must read” for anyone looking for a comprehensive yet accessible and up-to-date overview of the latest advances in cancer immunology and #immunotherapy.

We were delighted to work with Joe YEONG 杨宝诚 and colleagues Institute of Molecular and Cell Biology and Nanyang Technological University Singapore on the chapter: The Hurdle of Precision Medicine in Cancer Immunotherapy: Personalization Now or Then?

This chapter alone is a fascinating and important resource that raises important questions and suggestions for future research to advance this field.

Take a look: https://lnkd.in/dDpvq-AF

Congratulations to everyone involved in creating this important resource!