In Client successes

New publication success!

A collaborative team of researchers based at the Shanghai Institute of Immunology, the First affiliated hospital of Zhejiang University, the Singapore Immunology Network, the National University of Singapore (NUS), and the SingHealth Duke-NUS Academic Medical Center, have published the results of a superb study into how mutations in CSF-1R affect microglia to promote neurodegenerative disease.

The focus of this study was hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS) – a rare yet fatal neurodegenerative disease underpinned by mutations in CSF-IR. Wei Jie Wong and colleagues developed a state-of-the-art macrophage and forebrain organoid co-culture derived from induced pluripotent stem cells isolated from two patients with HDLS.

Compared to control organoids (in which CSF-1R gene mutations were corrected), they found that the patient-derived macrophages exhibited a metabolic shift towards the glycolytic pathway and reduced CSF-1 sensitivity. The result of this shift was an increase in IL-1β production and an activated inflammatory phenotype. RNA sequencing revealed that these macrophages existed in a reactive state, which led to impaired neuronal cell regulation.

This ground breaking study has provided yet more evidence of the diverse roles of microglia, as well as great insight into the pathological mechanisms of HDLS. We have no doubt that immunologists, neuroscientists, and clinicians will all be thrilled to read this exciting study and learn how Wei Jie Wong et al. tackled this complex question.

If you are interested to learn more, the paper is now available to download here, complete with referee reports: https://lnkd.in/dcY2kYxh

Many congratulations to the whole team: Wei Jie Wong, Yi Wen Zhu, Hai Ting Wang, Jia Wen Qian, Ziyi Li, Li Song, Zhao Yuan Liu, Wei Guo, Shuang Yan Zhang, Bing Su, Fang Ping He, Kang Wang and Florent Ginhoux!

In Blog

IEL’s Editorial Reports – Game-Changing Guidance Beyond the Tracked Changes

At the heart of Insight Editing London’s mission is our commitment to helping researchers’ work achieve its full publication potential, quickly and easily. Journal acceptance rates average 32%, while top-tier journals reject as many as 99% of submitted papers [1]; this means that researchers are having to spend more and more time and effort working to get their research out there, instead of following their passion at the bench. For us to help change that, we have to go the extra mile: when you work with an Insight Editor, you won’t just get a document back covered in in red marks, you get comments, questions, suggestions – and an Editorial Report.

 

What is an Editorial Report?

IEL has pioneered this addition to research editing services, because we – and our clients – see the added value of having a space in which to walk through a document together, taking in broader issues such as journal choice, in-context text originality, narrative flow, and future directions. Alongside directly editing the language and making the minor comments we would usually append to the main text, the Editorial Report covers each section in detail, and is where your editor will use their background as a researcher and well-read scientist to offer a scientific pre-review of your work that covers:

  • their overall interpretation interpretation of your work, how it sits within the broader field, and the future directions we could envision for it (often across novel fields that extend the impact of the study).
  • specific suggestions and explanations of how the opening sections can be enhanced and synergised to increase editorial appeal.
  • detailed insights into journal profiling and tailoring of the “pitch” (via the covering letter) as well as how to highlight the aspects of your study that are most appealing to your target publication.
  • section-by-section thoughts on enhancing your scientific communication, elucidating improvements, and addressing any queries we may have, from the triple-perspective of an editor, an avid reader, and a scientist.

 

How can an Editorial Report help me to publish my work?

The content and structure of the Editorial Report is designed to specifically address and help to remediate the most frequent reasons for rejection, as specified by major publishers [2]. Our distance from your study allows us to identify potential issues that may have “slipped through the cracks” while we refine the text, structure, and flow of your article. We then make sure that each section of your manuscript ticks all the boxes in terms of what it is supposed to achieve – from outlining the context and rationale of your work, to interpreting and speculating on the data you describe.

Our clients also find our Editorial Reports an invaluable point of reference for future manuscripts. They are filled with independent and practical tips and advice that can often be readily applied to other papers, saving researchers time and energy and helping to advance their own writing skillset.

 

Further support

For more advice and writing tips, see our blog articles or follow us on LinkedIn. Have a specific question? You can email us at enquiry@insighteditinglondon.com, or fill in the webform here and we’ll get back to you right away!

In News

Publication success!

We are delighted to see that the latest study on the mechanisms of chemo-resistance in T-cell Acute Lymphoblastic #Leukemia (T-ALL) by Jingliao Zhang and colleagues is now published in the prestigious journal, Blood!

T-ALL is an aggressive cancer not least because of the propagation of resistant cancer clones that drive disease recurrence. Jingliao Zhang et al. (Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College) wanted to dissect the nature of these clones to work out how their presences might contribute to resistance to #chemotherapy .

Combining single cell RNA sequencing with T-cell receptor sequencing of paired diagnosis-relapse T-ALL samples, the researchers identified two leukemic evolutionary patterns: “clonal shift” and “clonal drift”. They additionally saw high expression of the RNA-binding protein MSI2 in the clones persisting at the point of disease relapse. Digging deeper, the researchers conducted functional studies showing that MSI2 contributed to T-ALL proliferation and promoted #chemoresistance through the posttranscriptional regulation of the #oncogene, MYC.

These findings have important implications, as they identify MSI2 as an informative biomarker and novel therapeutic target in T-ALL.

Congratulations to all those involved in this intricate study! For those of you who would like to learn more, the paper can be found online here: https://lnkd.in/dcRJVgr9

In News

New insights into physiological and pathological brain wiring

We’re excited to share news of the publication of a fantastic article by an IEL client last month, edited by IEL’s Ilya Demchenko.

Published in PNAS as an open access article, Sinclair-Wilson and colleagues describe their ground-breaking work on the plasticity of brain circuits in neonates, which is important for the correction of embryonic thalamocortical axon mis-targeting. Using a genetic mouse model, the researchers identified a serotonin-dependent window in the immediate post-natal period in which pre-natal axon miswiring can be corrected and appropriate definition of cortical areas rescued: this period was disrupted by pre-term birth and dysregulation of serotonin levels. This work may have profound implications for our understanding of human neurodevelopmental disorders that occur in extremely pre-term infants.

You can find out everything you need to know by downloading the full text here: Plasticity of thalamocortical axons is regulated by serotonin levels modulated by preterm birth | PNAS

Well done to everyone involved in this groundbreaking study – it was a pleasure working with you and we look forward to learning how this work progresses in the future!

In Client successes

Researchers land Horizon Europe funding to tackle the burden of sepsis

Earlier this year, we had the great pleasure of working with Jan Frič and colleagues on their Horizon Europe proposal that aims to raise awareness and tackle the long-term consequences of sepsis.

We are delighted to share the news that this hugely exciting proposal has now been awarded a staggering 6.9 million euros! The consortium involved are already hard at work kick-starting their 5-year project titled “Biomarkers established to stratify sepsis long-term adverse effects to improve patients’ health and quality of life” – aka “BEATsep”.

We can’t wait to see how BEATsep progresses and to work with the team on their research outputs in the near future. For more information, check out their post below and their website: www.beatsepsis.eu

Huge congratulations to everyone involved!

In News

Publication success!

New findings on how pulmonary metastases form in gastric cancer (GC) have been published in the Journal of Cellular Biochemistry!

Ming Wang and colleagues at Henan University, investigated how extracellular vesicles known as exosomes might help GC cells metastasize to the lungs, using mouse forestomach carcinoma cells as their model system. They found a novel mechanism by which GC-derived exosomes mediate PD-L1 expression in lung macrophages (which helps cancer cells evade immune detection), which in turn facilitates lung pre-metastatic niche formation. Wang et al. hypothesize that these findings might one day translate into a future potential therapeutic target for GC with pulmonary metastases.

Find out more, here: https://onlinelibrary.wiley.com/doi/10.1002/jcb.30390

Well done to the authors involved in this insightful study – it was a pleasure to work with you and learn more about this exciting research!